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Target
Phosphatidylserine lipase ABHD16A
Ligand
BDBM50507489
Substrate
n/a
Meas. Tech.
ChEMBL_1830162 (CHEMBL4330036)
IC50
32±n/a nM
Citation
 Ahonen, TJ; Savinainen, JR; Yli-Kauhaluoma, J; Kalso, E; Laitinen, JT; Moreira, VM Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A. ACS Med Chem Lett 9:1269-1273 (2018) [PubMed]  Article 
Target
Name:
Phosphatidylserine lipase ABHD16A
Synonyms:
ABHD16A | ABHGA_HUMAN | BAT5 | G5 | NG26 | Protein BAT5
Type:
PROTEIN
Mol. Mass.:
63254.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_557683
Residue:
558
Sequence:
MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL
  
Inhibitor
Name:
BDBM50507489
Synonyms:
CHEMBL4564841
Type:
Small organic molecule
Emp. Form.:
C9H7FN2O3
Mol. Mass.:
210.1619
SMILES:
COc1nn(-c2ccc(F)cc2)c(=O)o1
Structure:
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