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Target
Phosphatidylserine lipase ABHD16A
Ligand
BDBM50336546
Substrate
n/a
Meas. Tech.
ChEMBL_1830167 (CHEMBL4330041)
IC50
57±n/a nM
Citation
 Ahonen, TJ; Savinainen, JR; Yli-Kauhaluoma, J; Kalso, E; Laitinen, JT; Moreira, VM Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A. ACS Med Chem Lett 9:1269-1273 (2018) [PubMed]  Article 
Target
Name:
Phosphatidylserine lipase ABHD16A
Synonyms:
ABHD16A | ABHGA_HUMAN | BAT5 | G5 | NG26 | Protein BAT5
Type:
PROTEIN
Mol. Mass.:
63254.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_557683
Residue:
558
Sequence:
MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTGVPFPQNEANAMDVVVQFAIHRLGFQPQDIIIYAWSIGGFTATWAAMSYPDVSAMILDASFDDLVPLALKVMPDSWRGLVTRTVRQHLNLNNAEQLCRYQGPVLLIRRTKDEIITTTVPEDIMSNRGNDLLLKLLQHRYPRVMAEEGLRVVRQWLEASSQLEEASIYSRWEVEEDWCLSVLRSYQAEHGPDFPWSVGEDMSADGRRQLALFLARKHLHNFEATHCTPLPAQNFQMPWHL
  
Inhibitor
Name:
BDBM50336546
Synonyms:
CHEMBL1673415 | Palmostatin B
Type:
Small organic molecule
Emp. Form.:
C23H36O4
Mol. Mass.:
376.5295
SMILES:
CCCCCCCCCC[C@H]1[C@H](CCc2ccc(OC)c(OC)c2)OC1=O |r|
Structure:
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