Target
Coagulation factor X
Ligand
BDBM50062693
Substrate
n/a
Meas. Tech.
ChEMBL_48636 (CHEMBL874700)
IC50
360±n/a nM
Citation
 Klein, SICzekaj, MGardner, CJGuertin, KRCheney, DLSpada, APBolton, SABrown, KColussi, DHeran, CLMorgan, SRLeadley, RJDunwiddie, CTPerrone, MHChu, V Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa. J Med Chem 41:437-50 (1998) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50062693
Synonyms:
Acetic acid (E)-3-[(biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enyl ester | CHEMBL138217
Type:
Small organic molecule
Emp. Form.:
C34H33N3O3
Mol. Mass.:
531.6441
SMILES:
CC(=O)OCC(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccccc1)\C=C\c1ccccc1
Structure:
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