Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50392863
Substrate
n/a
Meas. Tech.
ChEMBL_1887214 (CHEMBL4388891)
EC50
79±n/a nM
Citation
 Pio, B; Chobanian, HR; Guo, Y; Josien, H; Hagmann, WK; Miller, M; Trujillo, ME; Kirkland, M; Kosinski, D; Mane, J; Pachanski, M; Cheewatrakoolpong, B; Ashley, E; Orr, R; Wright, MJ; Bugianesi, R; Souza, S; Zhang, X; Di Salvo, J; Weinglass, AB; Tschirret-Guth, R; Samuel, K; Chen, Q; Shang, J; Lamca, J; Ehrhart, J; Nargund, R; Howard, AD; Colletti, SL Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs. Bioorg Med Chem Lett 29:1842-1848 (2019) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50392863
Synonyms:
CHEMBL2152069
Type:
Small organic molecule
Emp. Form.:
C26H25FO4
Mol. Mass.:
420.4727
SMILES:
COc1ccc(F)c(c1)-c1ccc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cc1 |r|
Structure:
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