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Target
Sterol O-acyltransferase 1
Ligand
BDBM50077652
Substrate
n/a
Meas. Tech.
ChEBML_28498
IC50
24000±n/a nM
Citation
 Kwon, BM; Kim, MK; Baek, NI; Kim, DS; Park, JD; Kim, YK; Lee, HK; Kim, SI Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins. Bioorg Med Chem Lett 9:1375-8 (1999) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50077652
Synonyms:
(3S,6S,8R,10R,12R,14R)-17-((S)-1-Hydroxy-1,5-dimethyl-hex-4-enyl)-4,4,8,10,14-pentamethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,6,12-triol | CHEMBL28423
Type:
Small organic molecule
Emp. Form.:
C30H52O4
Mol. Mass.:
476.7315
SMILES:
[#6]\[#6](-[#6])=[#6]/[#6]-[#6][C@]([#6])([#8])[#6]-1-[#6]-[#6][C@]2([#6])[#6]-1-[#6@H](-[#8])-[#6]-[#6]1[C@@]3([#6])[#6]-[#6]-[#6@H](-[#8])C([#6])([#6])[#6]3-[#6@@H](-[#8])-[#6][C@@]21[#6]
Structure:
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