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Target
Sterol O-acyltransferase 1
Ligand
BDBM50077654
Substrate
n/a
Meas. Tech.
ChEBML_28498
IC50
12000±n/a nM
Citation
 Kwon, BM; Kim, MK; Baek, NI; Kim, DS; Park, JD; Kim, YK; Lee, HK; Kim, SI Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins. Bioorg Med Chem Lett 9:1375-8 (1999) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50077654
Synonyms:
(3S,6S,8R,10R,12R,14R)-4,4,8,10,14-Pentamethyl-17-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-hexadecahydro-cyclopenta[a]phenanthrene-3,6,12-triol | CHEMBL283809
Type:
Small organic molecule
Emp. Form.:
C30H52O4
Mol. Mass.:
476.7315
SMILES:
C[C@@]12CCC(C1[C@H](O)CC1[C@@]3(C)CC[C@H](O)C(C)(C)C3[C@@H](O)C[C@@]21C)[C@@]1(C)CCCC(C)(C)O1
Structure:
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