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Target
Vasopressin V2 receptor
Ligand
BDBM50087669
Substrate
n/a
Meas. Tech.
ChEBML_214705
IC50
12±n/a nM
Citation
 Ashwell, MA; Bagli, JF; Caggiano, TJ; Chan, PS; Molinari, AJ; Palka, C; Park, CH; Rogers, JF; Sherman, M; Trybulski, EJ; Williams, DK The design, synthesis and physical chemical properties of novel human vasopressin V2-receptor antagonists optimized for parenteral delivery. Bioorg Med Chem Lett 10:783-6 (2000) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50087669
Synonyms:
Biphenyl-2-carboxylic acid {3-chloro-4-[3-(4-methyl-piperazine-1-carbonyl)-5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyl]-phenyl}-amide; compound with 3-carboxy-3-hydroxy-pentanedioic acid | CHEMBL164387
Type:
Small organic molecule
Emp. Form.:
C38H34ClN5O3
Mol. Mass.:
644.161
SMILES:
CN1CCN(CC1)C(=O)c1ccc2CN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccccc4)cc3Cl)c3ccccc3Cn12
Structure:
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