Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50088653
Substrate
n/a
Meas. Tech.
ChEMBL_213208 (CHEMBL818021)
Ki
420±n/a nM
Citation
 Coburn, CA; Rush, DM; Williams, PD; Homnick, C; Lyle, EA; Lewis, SD; Lucas, BJ; Di Muzio-Mower, JM; Juliano, M; Krueger, JA; Vastag, K; Chen, IW; Vacca, JP Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors. Bioorg Med Chem Lett 10:1069-72 (2000) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50088653
Synonyms:
CHEMBL274152 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-((R)-3-cyclobutylmethyl-6-methyl-2,8-dioxo-2,3,4,8-tetrahydro-1H-[1,7]naphthyridin-7-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C23H29N5O3
Mol. Mass.:
423.5081
SMILES:
Cc1cc2C[C@@H](CC3CCC3)C(=O)Nc2c(=O)n1CC(=O)NCc1ccc(N)nc1C
Structure:
Search PDB for entries with ligand similarity: