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Target
Neuromedin-K receptor
Ligand
BDBM50403793
Substrate
n/a
Meas. Tech.
ChEBML_209537
IC50
0.720000±n/a nM
Citation
 Nishi, T; Ishibashi, K; Takemoto, T; Nakajima, K; Fukazawa, T; Iio, Y; Itoh, K; Mukaiyama, O; Yamaguchi, T Combined tachykinin receptor antagonist: synthesis and stereochemical structure-activity relationships of novel morpholine analogues. Bioorg Med Chem Lett 10:1665-8 (2000) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK3R_CAVPO | Neurokinin 3 receptor | Neurokinin NK3 | Neuromedin-K receptor | TACR3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49456.44
Organism:
GUINEA PIG
Description:
Neurokinin NK3 TACR3 GUINEA PIG::P30098
Residue:
440
Sequence:
MASPAGNLSAWPGWGWPPPAALRNLTSSPAPTASPSPAPSWTPSPRPGPAHPFLQPPWAVALWSLAYGAVVAVAVLGNLVVIWIVLAHKRMRTVTNSFLVNLAFADAAMAALNALVNFIYALHGEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATRIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGSRQHFTYHMIVIVLVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYQEQLKAKRKVVKMMIIVVVTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIHVSSYDELELKATRLHPMRQSSLYTVTRMESMSVVFDSNDGDSARSSHQKRGTTRDVGSNVCSRRNSKSTSTTASFVSSSHMSVEEGS
  
Inhibitor
Name:
BDBM50403793
Synonyms:
CHEMBL2115415
Type:
Small organic molecule
Emp. Form.:
C34H38Cl2N2O6S
Mol. Mass.:
673.646
SMILES:
COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)c2ccccc2C[S@@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Structure:
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