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Target
C-C chemokine receptor type 1
Ligand
BDBM50098637
Substrate
n/a
Meas. Tech.
ChEMBL_218695 (CHEMBL821481)
IC50
270±n/a nM
Citation
 Naya, A; Sagara, Y; Ohwaki, K; Saeki, T; Ichikawa, D; Iwasawa, Y; Noguchi, K; Ohtake, N Design, synthesis, and discovery of a novel CCR1 antagonist. J Med Chem 44:1429-35 (2001) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | CC-CKR-1 | CCR-1 | CCR1_MOUSE | CD_antigen=CD191 | Ccr1 | Cmkbr1 | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R
Type:
PROTEIN
Mol. Mass.:
40904.59
Organism:
Mus musculus
Description:
ChEMBL_1452291
Residue:
355
Sequence:
MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50098637
Synonyms:
1-Cyclooctylmethyl-1-propyl-4-[(9H-xanthene-9-carbonyl)-amino]-piperidinium; iodide | CHEMBL33614
Type:
Small organic molecule
Emp. Form.:
C31H43N2O2
Mol. Mass.:
475.6848
SMILES:
CCC[N+]1(CC2CCCCCCC2)CCC(CC1)NC(=O)C1c2ccccc2Oc2ccccc12 |(3.85,.09,;3.46,-1.42,;1.96,-1.83,;1.58,-3.31,;2.91,-4.08,;4.46,-3.4,;5.89,-3.98,;7.31,-3.4,;7.89,-1.96,;7.31,-.56,;5.89,.03,;4.46,-.56,;3.89,-1.99,;.24,-2.57,;-1.09,-3.31,;-1.08,-4.85,;.27,-5.62,;1.61,-4.85,;-2.39,-5.65,;-3.72,-4.88,;-3.74,-3.34,;-5.05,-5.65,;-6.37,-4.88,;-6.37,-3.34,;-7.71,-2.57,;-9.05,-3.34,;-9.03,-4.88,;-7.72,-5.65,;-7.71,-7.19,;-6.4,-7.95,;-6.41,-9.46,;-5.08,-10.25,;-3.74,-9.49,;-3.74,-7.95,;-5.05,-7.19,)|
Structure:
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