Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50099490
Substrate
n/a
Meas. Tech.
ChEBML_153391
EC50
100±n/a nM
Citation
Brown, PJ; Stuart, LW; Hurley, KP; Lewis, MC; Winegar, DA; Wilson, JG; Wilkison, WO; Ittoop, OR; Willson, TM Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. Bioorg Med Chem Lett 11:1225-7 (2001) [PubMed] Article
More Info.:
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Inhibitor
Name:
BDBM50099490
Synonyms:
2-(4-{2-[1-(2-Biphenyl-4-yl-ethyl)-3-(2-methoxy-5-methyl-phenyl)-ureido]-ethyl}-phenylsulfanyl)-2-methyl-propionic acid | CHEMBL21105
Type:
Small organic molecule
Emp. Form.:
C35H38N2O4S
Mol. Mass.:
582.752
SMILES:
COc1ccc(C)cc1NC(=O)N(CCc1ccc(SC(C)(C)C(O)=O)cc1)CCc1ccc(cc1)-c1ccccc1