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Target
Plasminogen activator inhibitor 1
Ligand
BDBM50116755
Substrate
n/a
Meas. Tech.
ChEBML_155614
IC50
8600±n/a nM
Citation
 Wang, S; Golec, J; Miller, W; Milutinovic, S; Folkes, A; Williams, S; Brooks, T; Hardman, K; Charlton, P; Wren, S; Spencer, J Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines. Bioorg Med Chem Lett 12:2367-70 (2002) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM50116755
Synonyms:
CHEMBL421503 | N-{4-[1,4-Dioxo-1,4-dihydro-2H-isoquinolin-(3Z)-ylidenemethyl]-phenyl}-benzamide
Type:
Small organic molecule
Emp. Form.:
C23H16N2O3
Mol. Mass.:
368.3847
SMILES:
O=C(Nc1ccc(\C=C2/NC(=O)c3ccccc3C2=O)cc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: