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Target
Plasminogen activator inhibitor 1
Ligand
BDBM50116756
Substrate
n/a
Meas. Tech.
ChEBML_155614
IC50
>50000±n/a nM
Citation
 Wang, S; Golec, J; Miller, W; Milutinovic, S; Folkes, A; Williams, S; Brooks, T; Hardman, K; Charlton, P; Wren, S; Spencer, J Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines. Bioorg Med Chem Lett 12:2367-70 (2002) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM50116756
Synonyms:
3-[1-Phenyl-meth-(Z)-ylidene]-6-[1-[5-(3-pyridin-3-yl-propoxy)-pyridin-2-yl]-meth-(Z)-ylidene]-piperazine-2,5-dione | CHEMBL77248
Type:
Small organic molecule
Emp. Form.:
C25H22N4O3
Mol. Mass.:
426.4672
SMILES:
O=c1[nH]\c(=C/c2ccc(OCCCc3cccnc3)cn2)c(=O)[nH]\c1=C/c1ccccc1
Structure:
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