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Target
Vasopressin V2 receptor
Ligand
BDBM50125112
Substrate
n/a
Meas. Tech.
ChEBML_214716
IC50
8±n/a nM
Citation
 Matthews, JM; Greco, MN; Hecker, LR; Hoekstra, WJ; Andrade-Gordon, P; de Garavilla, L; Demarest, KT; Ericson, E; Gunnet, JW; Hageman, W; Look, R; Moore, JB; Maryanoff, BE Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists. Bioorg Med Chem Lett 13:753-6 (2003) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50125112
Synonyms:
Biphenyl-2-carboxylic acid [4-(2-oxo-1,2,2a,3,4,5-hexahydro-azepino[4,3,2-cd]indole-6-carbonyl)-phenyl]-amide | CHEMBL350576
Type:
Small organic molecule
Emp. Form.:
C31H25N3O3
Mol. Mass.:
487.5485
SMILES:
O=C(Nc1ccc(cc1)C(=O)N1CCCC2C(=O)Nc3cccc1c23)c1ccccc1-c1ccccc1
Structure:
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