Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM50133460
Substrate
n/a
Meas. Tech.
ChEMBL_1718 (CHEMBL616924)
Ki
8±n/a nM
Citation
 Egle, I; MacLean, N; Demchyshyn, L; Edwards, L; Slassi, A; Tehim, A (R)-3-(N-methylpyrrolidin-2-ylmethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity h5-HT1B/1D ligands. Bioorg Med Chem Lett 13:3419-21 (2003) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM50133460
Synonyms:
CHEMBL115415 | Dimethyl-{2-[5-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indol-3-yl]-ethyl}-amine
Type:
Small organic molecule
Emp. Form.:
C18H25N3
Mol. Mass.:
283.4112
SMILES:
CN(C)CCc1c[nH]c2ccc(cc12)C1=CCN(C)CC1 |t:16|
Structure:
Search PDB for entries with ligand similarity: