Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM50146568
Substrate
n/a
Meas. Tech.
ChEBML_214408
IC50
20±n/a nM
Citation
 Xiang, MA; Chen, RH; Demarest, KT; Gunnet, J; Look, R; Hageman, W; Murray, WV; Combs, DW; Patel, M Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists. Bioorg Med Chem Lett 14:2987-9 (2004) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50146568
Synonyms:
CHEMBL101935 | spirobenzoxazines analogues
Type:
Small organic molecule
Emp. Form.:
C29H28N2O2
Mol. Mass.:
436.5448
SMILES:
O=C(Nc1ccc(cc1)C(=O)N1CCC2(CCCC=C2)Cc2ccccc12)c1ccccc1 |c:19|
Structure:
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