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Found 396 with Last Name = 'combs' and Initial = 'dw'
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50146577(CHEMBL102311 | spirobenzoxazines analogues)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347329(CHEMBL1796851)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347323(CHEMBL1796845)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347327(CHEMBL1796849)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347324(CHEMBL1796846)
Affinity DataIC50:  2nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50366915(CHEMBL1788220)
Affinity DataIC50:  2nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347327(CHEMBL1796849)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347328(CHEMBL1796850)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM22266(2,4,5-tri-substituted imidazole, 21n | {ethyl[(3R)...)
Affinity DataIC50:  3nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347325(CHEMBL1796847)
Affinity DataIC50:  3nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347329(CHEMBL1796851)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50148732(17-ethynyl-17beta-hydroxyestr-4-en-3-one | 17alpha...)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells was determined using (Z)-[125I]-17-alpha-(2-iodovinyl)-19-nor-testost...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347322(CHEMBL1796844)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147223(3'N-(2-hydroxyethyl)-1-[4-(2-fluorophenylcarboxami...)
Affinity DataIC50:  4nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347318(CHEMBL1796840)
Affinity DataIC50:  4nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147224(3'N-(2-dimethylaminoethyl)-1-[4-(2-phenylphenylcar...)
Affinity DataIC50:  4nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50366914(CHEMBL1788221)
Affinity DataIC50:  4nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147220(4-{2-[1-[4-(2-fluorophenylcarboxamido)benzoyl]spir...)
Affinity DataIC50:  4nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147227(3'N-(3-dimethylaminopropyl)-1-[4-(5-fluoro-2-methy...)
Affinity DataIC50:  4nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347328(CHEMBL1796850)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347330(CHEMBL1795361)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347323(CHEMBL1796845)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147227(3'N-(3-dimethylaminopropyl)-1-[4-(5-fluoro-2-methy...)
Affinity DataIC50:  5nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147224(3'N-(2-dimethylaminoethyl)-1-[4-(2-phenylphenylcar...)
Affinity DataIC50:  5nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Rattus norvegicus (Rat))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50366915(CHEMBL1788220)
Affinity DataIC50:  5nMAssay Description:Evaluated for binding affinity towards vasopressin V2 receptor in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  5nMAssay Description:Binding affinity towards human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147219(3'N-(2-dimethylaminoethyl)-1-[4-(5-fluoro-2-methyl...)
Affinity DataIC50:  5nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147228(3'N-(3-dimethylaminopropyl)-1-[4-(2-phenylphenylca...)
Affinity DataIC50:  5nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147221(3'N-(2-hydroxyethyl)-1-[4-(2-phenylphenylcarboxami...)
Affinity DataIC50:  5nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347326(CHEMBL1796848)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147221(3'N-(2-hydroxyethyl)-1-[4-(2-phenylphenylcarboxami...)
Affinity DataIC50:  6nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104856(CHEMBL51363 | N-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM22249(2,4,5-tri-substituted imidazole, 14n | N-{2-[5-(4-...)
Affinity DataIC50:  6nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM22302(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50:  6nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347325(CHEMBL1796847)
Affinity DataIC50:  7nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347324(CHEMBL1796846)
Affinity DataIC50:  7nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147225(3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(2-fluorop...)
Affinity DataIC50:  7nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147230(CHEMBL319636 | methyl 2-[1-[4-(5-fluoro-2-methylph...)
Affinity DataIC50:  7nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347322(CHEMBL1796844)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50366915(CHEMBL1788220)
Affinity DataIC50:  8nMAssay Description:Evaluated for intracellular calcium mobilization in HEK- 293 cells transfected to express human vasopressin V1a receptor (Compound 7o)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147222(3'N-(2-dimethylaminoethyl)-1-[4-(2-fluorophenylcar...)
Affinity DataIC50:  8nMAssay Description:Evaluated for intracellular calcium mobilization in HEK293 cells transfected to express human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147229(3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(5-fluoro-...)
Affinity DataIC50:  8nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human V2 receptor (Compound 7o)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50137552(5-[(1R,3S)-3-(3,5-Dichloro-phenyl)-2,2-dimethyl-cy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50146578(CHEMBL103406 | spirobenzoxazines analogues)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory concentration against [3H]-AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM22304(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Affinity DataIC50:  8nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147226(3'N-(2-tetrahydro-1H-1-pyrrolylethyl)-1-[4-(2-fluo...)
Affinity DataIC50:  8nMAssay Description:Binding affinity measured by inhibition of 3[H] AVP binding to cloned human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347326(CHEMBL1796848)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of rabbit 15-LO using arachidonic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50347319(CHEMBL1796841)
Affinity DataIC50:  9nMAssay Description:Inhibition of rabbit 15-LO using linoleic acid by standard colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104844(BMS-284640 | CHEMBL51879 | N-[(1R,3R)-3-(2,3-Dihyd...)
Affinity DataIC50:  9nMAssay Description:Inhibition of sodium dependent recovery of pH following imposed acidosis in AP1 cell line expressing the human NHE-1 isoform.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson And Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50147229(3'N-(2-hexahydro-1-pyridinylethyl)-1-[4-(5-fluoro-...)
Affinity DataIC50:  9nMAssay Description:Evaluated for accumulation of cAMP in transfected HEK293 cells expressing human V2 receptor (Compound 7o)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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