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Target
Vasopressin V2 receptor
Ligand
BDBM50146568
Substrate
n/a
Meas. Tech.
ChEBML_215032
IC50
390±n/a nM
Citation
 Xiang, MA; Chen, RH; Demarest, KT; Gunnet, J; Look, R; Hageman, W; Murray, WV; Combs, DW; Patel, M Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists. Bioorg Med Chem Lett 14:2987-9 (2004) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50146568
Synonyms:
CHEMBL101935 | spirobenzoxazines analogues
Type:
Small organic molecule
Emp. Form.:
C29H28N2O2
Mol. Mass.:
436.5448
SMILES:
O=C(Nc1ccc(cc1)C(=O)N1CCC2(CCCC=C2)Cc2ccccc12)c1ccccc1 |c:19|
Structure:
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