Reaction Details Report a problem with these data
Target
Plasminogen
Ligand
BDBM50147046
Substrate
n/a
Meas. Tech.
ChEBML_155602
Ki
5000±n/a nM
Citation
 Subasinghe, NL; Ali, F; Illig, CR; Jonathan Rudolph, M; Klein, S; Khalil, E; Soll, RM; Bone, RF; Spurlino, JC; DesJarlais, RL; Crysler, CS; Cummings, MD; Morris, PE; Kilpatrick, JM; Sudhakara Babu, Y A novel series of potent and selective small molecule inhibitors of the complement component C1s. Bioorg Med Chem Lett 14:3043-7 (2004) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
PLMN_RAT | Plasmin | Plasminogen | Plg
Type:
Protein
Mol. Mass.:
90541.87
Organism:
Rattus norvegicus
Description:
Q01177
Residue:
812
Sequence:
MDHKEIILLFLLFLKPGQGDSLDGYVSTQGASLHSLTKKQLAAGSIADCLAKCEGETDFICRSFQYHSKEQQCVIMAENSKTSSIIRMRDVILFEKRVYLSECKTGIGKGYRGTMSKTKTGVTCQKWSDTSPHVPKYSPSTHPSEGLEENYCRNPDNDEQGPWCYTTDPDQRYEYCNIPECEEECMYCSGEKYEGKISKTMSGLDCQSWDSQSPHAHGYIPAKFPSKNLKMNYCRNPDGEPRPWCFTTDPNKRWEYCDIPRCTTPPPPPGPTYQCLKGRGENYRGTVSVTASGKTCQRWSEQTPHRHNRTPENFPCKNLEENYCRNPDGETAPWCYTTDSQLRWEYCEIPSCGSSVSPDQSDSSVLPEQTPVVQECYQGNGKSYRGTSSTTNTGKKCQSWVSMTPHSHSKTPANFPDAGLEMNYCRNPDNDQRGPWCFTTDPSVRWEYCNLKRCSETGGGVAESAIVPQVPSAPGTSETDCMYGNGKEYRGKTAVTAAGTPCQEWAAQEPHSHRIFTPQTNPRAGLEKNYCRNPDGDVNGPWCYTMNPRKLYDYCNIPLCASLSSFECGKPQVEPKKCPGRVVGGCVANPHSWPWQISLRTRFSGQHFCGGTLISPEWVLTAAHCLEKSSRPEFYKVILGAHEERILGSDVQQIAVTKLVLEPNDADIALLKLSRPATITDNVIPACLPSPNYVVADRTLCYITGWGETKGTPGAGRLKEAQLPVIENKVCNRAEYLNNRVKSTELCAGHLAGGIDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRYVNWIEREMRND
  
Inhibitor
Name:
BDBM50147046
Synonyms:
5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H-pyrazol-4-yl)-thiazol-2-yl]-thiophene-2-carboxamidine | CHEMBL317917
Type:
Small organic molecule
Emp. Form.:
C20H20N6OS3
Mol. Mass.:
456.607
SMILES:
CCCOc1c(cnn1-c1ccccn1)-c1csc(n1)-c1cc(sc1SC)C(N)=N
Structure:
Search PDB for entries with ligand similarity: