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Target
Inward rectifier potassium channel 13
Ligand
BDBM194954
Substrate
n/a
Meas. Tech.
ChEMBL_2155295 (CHEMBL5039955)
IC50
>100000±n/a nM
Citation
 Jiang, J; Ding, FX; Zhou, X; Bateman, TJ; Dong, S; Gu, X; Keh deJesus, R; Pio, B; Tang, H; Chobanian, HR; Levorse, D; Hu, M; Thomas-Fowlkes, B; Margulis, M; Koehler, M; Weinglass, A; Gibson, J; Houle, K; Yudkovitz, J; Hampton, C; Pai, LY; Samuel, K; Cutarelli, T; Sullivan, K; Parmee, ER; Davies, I; Pasternak, A Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic. J Med Chem 64:7691-7701 (2021) [PubMed]  Article 
Target
Name:
Inward rectifier potassium channel 13
Synonyms:
Inward rectifier K(+) channel Kir7.1 | KCJ13_HUMAN | KCNJ13 | Potassium channel, inwardly rectifying subfamily J member 13
Type:
PROTEIN
Mol. Mass.:
40527.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105176
Residue:
360
Sequence:
MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAHMDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFPLTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFASLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE
  
Inhibitor
Name:
BDBM194954
Synonyms:
US9206198, 7
Type:
Small organic molecule
Emp. Form.:
C24H28N2O6
Mol. Mass.:
440.4889
SMILES:
CC1=C(COC1=O)N1CCC2(CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2)C1=O |r,t:1|
Structure:
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