Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50584465
Substrate
n/a
Meas. Tech.
ChEMBL_2160024 (CHEMBL5044774)
EC50
17±n/a nM
Citation
 Feng, Z; Xiang, J; Liu, H; Li, J; Xu, X; Sun, G; Zheng, R; Zhang, S; Liu, J; Yang, S; Xu, Q; Wen, X; Yuan, H; Sun, H; Dai, L Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPAR?/? Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem 65:2571-2592 (2022) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_MOUSE | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara
Type:
PROTEIN
Mol. Mass.:
52343.28
Organism:
Mus musculus
Description:
ChEMBL_572395
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSIGEESSGSFGFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPVIPASTDESPGSALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLGKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50584465
Synonyms:
CHEMBL5084377
Type:
Small organic molecule
Emp. Form.:
C22H22F3N3O5
Mol. Mass.:
465.4224
SMILES:
Cc1cc(Cn2ncn(-c3ccc(OC(F)(F)F)cc3)c2=O)cc(C)c1OC(C)(C)C(O)=O
Structure:
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