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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50586984
Substrate
n/a
Meas. Tech.
ChEMBL_2170289 (CHEMBL5055348)
IC50
51±n/a nM
Citation
 Kroth, H; Oden, F; Serra, AM; Molette, J; Mueller, A; Berndt, M; Capotosti, F; Gabellieri, E; Schmitt-Willich, H; Hickman, D; Pfeifer, A; Dinkelborg, L; Stephens, A Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core. Bioorg Med Chem 52:0 (2021) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_MOUSE | Amine oxidase [flavin-containing] A | MAO-A | Maoa | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A
Type:
PROTEIN
Mol. Mass.:
59608.24
Organism:
Mus musculus
Description:
ChEMBL_122776
Residue:
526
Sequence:
MTDLEKPSITGHMFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDDMGKEIPVDAPWQARHAEEWDKITMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTSRIFSVTNGGQERKFVGGSGQISEQIMVLLGDKVKLSSPVTYIDQTDDNIIIETLNHEHYECKYVISAIPPVLTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSMPAIMGFILARKAERLAKLHKDIRKRKICELYAKVLGSQEALSPVHYEEKNWCEEQYSGGCYTAYFPPGIMTLYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVQEPESKDVPALEITHTFLERNLPSVPGLLKITGFSTSVALLCFVLYKFKQPQS
  
Inhibitor
Name:
BDBM50586984
Synonyms:
CHEMBL5084771
Type:
Small organic molecule
Emp. Form.:
C16H10FN3
Mol. Mass.:
263.2691
SMILES:
Fc1cc(ccn1)-c1ccc2c(c1)[nH]c1ccncc21
Structure:
Search PDB for entries with ligand similarity: