Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50161191
Substrate
n/a
Meas. Tech.
ChEMBL_302173 (CHEMBL830076)
Kd
14.8±n/a nM
Citation
 Oishi, S; Karki, RG; Kang, SU; Wang, X; Worthy, KM; Bindu, LK; Nicklaus, MC; Fisher, RJ; Burke, TR Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics. J Med Chem 48:764-72 (2005) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50161191
Synonyms:
(S)-4-{2-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-ethylcarbamoyl}-5-[4-(1-phosphono-ethyl)-phenyl]-pentanoic acid | CHEMBL414820
Type:
Small organic molecule
Emp. Form.:
C34H43N4O9P
Mol. Mass.:
682.7004
SMILES:
NC(=O)C[C@H](NC(=O)CCCCNC(=O)[C@@H](CC(O)=O)Cc1ccc(CP(O)(O)=O)cc1)C(=O)NCCCc1cccc2ccccc12
Structure:
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