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Target
Glucagon receptor
Ligand
BDBM50410090
Substrate
n/a
Meas. Tech.
ChEMBL_306583 (CHEMBL832930)
IC50
368±n/a nM
Citation
 Duffy, JL; Kirk, BA; Konteatis, Z; Campbell, EL; Liang, R; Brady, EJ; Candelore, MR; Ding, VD; Jiang, G; Liu, F; Qureshi, SA; Saperstein, R; Szalkowski, D; Tong, S; Tota, LM; Xie, D; Yang, X; Zafian, P; Zheng, S; Chapman, KT; Zhang, BB; Tata, JR Discovery and investigation of a novel class of thiophene-derived antagonists of the human glucagon receptor. Bioorg Med Chem Lett 15:1401-5 (2005) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50410090
Synonyms:
CHEMBL2112991
Type:
Small organic molecule
Emp. Form.:
C18H24N4O2S
Mol. Mass.:
360.474
SMILES:
CCC(CC)C(=O)Nc1sc(c(C)c1C#N)-c1nc(CC(C)C)no1
Structure:
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