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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50079387
Substrate
n/a
Meas. Tech.
ChEMBL_2210233 (CHEMBL5123182)
Ki
94±n/a nM
Citation
 Bechthold, E; Schreiber, JA; Ritter, N; Schepmann, D; Daniliuc, C; Seebohm, G; Wünsch, B Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil. Eur J Med Chem 237:0 (2022) [PubMed] 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50079387
Synonyms:
1-(4-Chloro-phenyl)-2-[4-(4-fluoro-benzyl)-piperidin-1-yl]-ethanol | CHEMBL28564 | Eliprodil
Type:
Small organic molecule
Emp. Form.:
C20H23ClFNO
Mol. Mass.:
347.854
SMILES:
OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Structure:
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