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Target
RNA-directed RNA polymerase
Ligand
BDBM50169904
Substrate
n/a
Meas. Tech.
ChEMBL_305910 (CHEMBL832625)
IC50
9±n/a nM
Citation
 Harper, S; Avolio, S; Pacini, B; Di Filippo, M; Altamura, S; Tomei, L; Paonessa, G; Di Marco, S; Carfi, A; Giuliano, C; Padron, J; Bonelli, F; Migliaccio, G; De Francesco, R; Laufer, R; Rowley, M; Narjes, F Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase. J Med Chem 48:4547-57 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50169904
Synonyms:
2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-diethylamino-piperidin-1-yl)-2-oxo-ethyl]-1H-indole-6-carboxylic acid | 2-(4-chlorophenyl)-3-cyclohexyl-1-(2-(4-(diethylamino)piperidin-1-yl)-2-oxoethyl)-1H-indole-6-carboxylic acid | CHEMBL362909
Type:
Small organic molecule
Emp. Form.:
C32H40ClN3O3
Mol. Mass.:
550.131
SMILES:
CCN(CC)C1CCN(CC1)C(=O)Cn1c(c(C2CCCCC2)c2ccc(cc12)C(O)=O)-c1ccc(Cl)cc1
Structure:
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