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Found 221 with Last Name = 'giuliano' and Initial = 'c'
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485494(CHEMBL2063089)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease D168V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485491(CHEMBL2063088)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease D168V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease D168V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485491(CHEMBL2063088)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485494(CHEMBL2063089)
Affinity DataKi:  2.90nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataKi:  5.30nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485494(CHEMBL2063089)
Affinity DataKi:  5.70nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485491(CHEMBL2063088)
Affinity DataKi:  11nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485490(CHEMBL2063087)
Affinity DataKi:  12nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataKi:  12nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485495(CHEMBL2063085)
Affinity DataKi:  18nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)
Affinity DataKi:  22nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485493(CHEMBL2063086)
Affinity DataKi:  27nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485489(CHEMBL1672609 | MK-1220)
Affinity DataKi:  27nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease D168V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485490(CHEMBL2063087)
Affinity DataKi:  64nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)
Affinity DataKi:  77nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease D168V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485495(CHEMBL2063085)
Affinity DataKi:  79nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485493(CHEMBL2063086)
Affinity DataKi:  80nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50326055((1R,21S,24S)-21-tert-Butyl-N-((1R,2R)-1-{[(cyclopr...)
Affinity DataKi:  88nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485489(CHEMBL1672609 | MK-1220)
Affinity DataKi:  540nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156T mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50485489(CHEMBL1672609 | MK-1220)
Affinity DataKi:  790nMAssay Description:Inhibition of Hepatitis C virus (isolate BK) genotype 1b NS3/4a protease A156V mutant expressed in Escherichia coli by time-resolved fluorescence ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352268(CHEMBL1822467)
Affinity DataIC50:  5nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352268(CHEMBL1822467)
Affinity DataIC50:  6nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169942(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-methanesu...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352269(CHEMBL1822466)
Affinity DataIC50:  8nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169930(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(cyclopropylme...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169911(3-Cyclohexyl-1-[2-(2-diethylaminomethyl-morpholin-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169922(3-Cyclohexyl-1-[2-(4-diethylamino-piperidin-1-yl)-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169906(3-Cyclohexyl-1-[2-(2-diethylaminomethyl-morpholin-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169899(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169904(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-diethylam...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352270(CHEMBL1822465)
Affinity DataIC50:  10nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352269(CHEMBL1822466)
Affinity DataIC50:  10nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169903(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(isopropyl-met...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169915(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(1,1-dioxo-1...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169931(2-(4-Chloro-phenyl)-3-cyclohexyl-1-{[methyl-(1-met...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169920(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-methyl-pi...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352296(CHEMBL1822468)
Affinity DataIC50:  13nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352296(CHEMBL1822468)
Affinity DataIC50:  13nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169919(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-dimethyla...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352271(CHEMBL1822463)
Affinity DataIC50:  15nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352270(CHEMBL1822465)
Affinity DataIC50:  15nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352272(CHEMBL1822447)
Affinity DataIC50:  16nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352271(CHEMBL1822463)
Affinity DataIC50:  17nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169932(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(dimethylcarba...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169921(3-Cyclohexyl-2-[3-(3,3-difluoro-piperidin-1-ylmeth...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169929(2-Cyclohex-1-enyl-3-cyclohexyl-1-[2-(4-dimethylami...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169916(3-Cyclohexyl-1-{[methyl-(1-methyl-piperidin-3-ylme...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50352273(CHEMBL1822464)
Affinity DataIC50:  19nMAssay Description:Displacement of BODIPY-cyclopamine from Smo expressed in COS-1 cells after 4 to 6 hrs by Flow Cytometry analysis in presence of 20% normal human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169910(3-Cyclohexyl-1-[2-(4-methanesulfonyl-piperazin-1-y...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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