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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50184653
Substrate
n/a
Meas. Tech.
ChEMBL_355606 (CHEMBL853178)
EC50
490±n/a nM
Citation
 Epple, R; Azimioara, M; Russo, R; Bursulaya, B; Tian, SS; Gerken, A; Iskandar, M 1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists. Bioorg Med Chem Lett 16:2969-73 (2006) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50184653
Synonyms:
CHEMBL210873 | [4-(4,4''-bis-dimethylamino-[1,1';3',1'']terphenyl-5'-ylmethoxy)-2-methyl-phenoxy]-acetic acid
Type:
Small organic molecule
Emp. Form.:
C32H34N2O4
Mol. Mass.:
510.6234
SMILES:
CN(C)c1ccc(cc1)-c1cc(COc2ccc(OCC(O)=O)c(C)c2)cc(c1)-c1ccc(cc1)N(C)C
Structure:
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