Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 3
Ligand
BDBM50604569
Substrate
n/a
Meas. Tech.
ChEMBL_2248266 (CHEMBL5162476)
EC50
22180±n/a nM
Citation
 Smith, RJ; Perez-Ternero, C; Conole, D; Martin, C; Myers, SH; Hobbs, AJ; Selwood, DL A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem 65:5495-5513 (2022) [PubMed] 
Target
Name:
Atrial natriuretic peptide receptor 3
Synonyms:
ANP-C | ANPR-C | ANPRC_RAT | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor type C | Npr-c | Npr3
Type:
PROTEIN
Mol. Mass.:
59731.56
Organism:
Rattus norvegicus
Description:
ChEMBL_120672
Residue:
535
Sequence:
MRSLLLFTFSACVLLARALLAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHRELREDSIRSHFSVA
  
Inhibitor
Name:
BDBM50604569
Synonyms:
CHEMBL5170051
Type:
Small organic molecule
Emp. Form.:
C17H22N6O3
Mol. Mass.:
358.395
SMILES:
CC(C)C[C@H](Nc1ncnc(Nc2ccc(NC(C)=O)cc2)n1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: