Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 3
Ligand
BDBM50604572
Substrate
n/a
Meas. Tech.
ChEMBL_2248267 (CHEMBL5162477)
EC50
3760±n/a nM
Citation
 Smith, RJ; Perez-Ternero, C; Conole, D; Martin, C; Myers, SH; Hobbs, AJ; Selwood, DL A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem 65:5495-5513 (2022) [PubMed] 
Target
Name:
Atrial natriuretic peptide receptor 3
Synonyms:
ANP-C | ANPR-C | ANPRC_RAT | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor type C | Npr-c | Npr3
Type:
PROTEIN
Mol. Mass.:
59731.56
Organism:
Rattus norvegicus
Description:
ChEMBL_120672
Residue:
535
Sequence:
MRSLLLFTFSACVLLARALLAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHRELREDSIRSHFSVA
  
Inhibitor
Name:
BDBM50604572
Synonyms:
CHEMBL5208520
Type:
Small organic molecule
Emp. Form.:
C25H30N6O3
Mol. Mass.:
462.5441
SMILES:
CC(=O)Nc1ccc(Nc2ncnc(N[C@@H](CCc3ccccc3)C(=O)OC(C)(C)C)n2)cc1 |r|
Structure:
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