Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50189187
Substrate
n/a
Meas. Tech.
ChEMBL_404878 (CHEMBL869282)
Ki
2600±n/a nM
Citation
Jiang, W; Tucci, FC; Chen, CW; Arellano, M; Tran, JA; White, NS; Marinkovic, D; Pontillo, J; Fleck, BA; Wen, J; Saunders, J; Madan, A; Foster, AC; Chen, C Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett 16:4674-8 (2006) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Inhibitor
Name:
BDBM50189187
Synonyms:
3-(2,4-dichlorophenyl)-1-(4-(2-((1S)-2-methyl-1-(phenethylamino)butyl)-4-(trifluoromethyl)phenyl)piperazin-1-yl)propan-1-one | CHEMBL385437
Type:
Small organic molecule
Emp. Form.:
C33H38Cl2F3N3O
Mol. Mass.:
620.576
SMILES:
CCC(C)[C@H](NCCc1ccccc1)c1cc(ccc1N1CCN(CC1)C(=O)CCc1ccc(Cl)cc1Cl)C(F)(F)F