Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50606942
Substrate
n/a
Meas. Tech.
ChEMBL_2261711 (CHEMBL5216722)
IC50
1330±n/a nM
Citation
 Capstick, RA; Whomble, D; Orsi, DL; Felts, AS; Rodriguez, AL; Vinson, PN; Chang, S; Blobaum, AL; Niswender, CM; Conn, PJ; Jones, CK; Lindsley, CW; Han, C Discovery of a potent M Bioorg Med Chem Lett 76:0 (2022) [PubMed] 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60161.80
Organism:
RAT
Description:
Cholinergic, muscarinic M5 CHRM5 RAT::P08911
Residue:
531
Sequence:
MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50606942
Synonyms:
CHEMBL5218950
Type:
Small organic molecule
Emp. Form.:
C18H21N5O3S2
Mol. Mass.:
419.521
SMILES:
Cc1nn(C)cc1S(=O)(=O)N1CCC(CC1)C(=O)Nc1ccc2scnc2c1
Structure:
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