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Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50195491
Substrate
n/a
Meas. Tech.
ChEMBL_425008 (CHEMBL911428)
IC50
>10000±n/a nM
Citation
 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome. Bioorg Med Chem Lett 16:6241-5 (2006) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-beta-hydroxysteroid dehydrogenase 2 | DHI2_RAT | Hsd11b2 | Hsd11k
Type:
PROTEIN
Mol. Mass.:
43740.05
Organism:
Rat
Description:
ChEMBL_735659
Residue:
400
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGPGALELRARCSPRLKLLQMDLTKPEDISRVLEITKAHTASTGLWGLVNNAGLNMVVADVELSPVVTFRECMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWGIKVSIIQPGCFKTEAVTNVNLWEKRKQLLLANLPRELLQAYGEDYIEHLHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYTGRGLGLMYFIHHYLPGGLRRRFLQNFFISHLLPRALRPGQPGPVHDTTQDPNPSPTVSAL
  
Inhibitor
Name:
BDBM50195491
Synonyms:
(4-amino-3,5-dichlorophenyl)(3-benzyl-3,6-diaza-bicyclo[3.2.1]octan-6-yl)methanone | CHEMBL220385
Type:
Small organic molecule
Emp. Form.:
C20H21Cl2N3O
Mol. Mass.:
390.306
SMILES:
Nc1c(Cl)cc(cc1Cl)C(=O)N1CC2CC1CN(Cc1ccccc1)C2
Structure:
Search PDB for entries with ligand similarity: