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Target
Hexokinase-4
Ligand
BDBM50615267
Substrate
n/a
Meas. Tech.
ChEMBL_2300654
EC50
>10000±n/a nM
Citation
 Deshpande, AM; Bhuniya, D; De, S; Dave, B; Vyavahare, VP; Kurhade, SH; Kandalkar, SR; Naik, KP; Kobal, BS; Kaduskar, RD; Basu, S; Jain, V; Patil, P; Chaturvedi Joshi, S; Bhat, G; Raje, AA; Reddy, S; Gundu, J; Madgula, V; Tambe, S; Shitole, P; Umrani, D; Chugh, A; Palle, VP; Mookhtiar, KA Discovery of liver-directed glucokinase activator having anti-hyperglycemic effect without hypoglycemia. Eur J Med Chem 133:268-286 (2017) [PubMed] 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50615267
Synonyms:
CHEMBL5288503
Type:
Small organic molecule
Emp. Form.:
C26H25F2N3O6S2
Mol. Mass.:
577.62
SMILES:
OC(=O)C1CCCN1Cc1cnc(NC(=O)C(Oc2ccc(F)cc2F)c2ccc(cc2)S(=O)(=O)C2CC2)s1
Structure:
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