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Target
Procathepsin L
Ligand
BDBM50201705
Substrate
n/a
Meas. Tech.
ChEMBL_438180 (CHEMBL907573)
IC50
263±n/a nM
Citation
 Epple, R; Urbina, HD; Russo, R; Liu, H; Mason, D; Bursulaya, B; Tumanut, C; Li, J; Harris, JL Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorg Med Chem Lett 17:1254-9 (2007) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50201705
Synonyms:
(1R,2S)-2-(benzyloxy)-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one | CHEMBL390475
Type:
Small organic molecule
Emp. Form.:
C13H15NO3
Mol. Mass.:
233.2631
SMILES:
O=C1O[C@@H]2CN1CC[C@@H]2OCc1ccccc1
Structure:
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