Reaction Details Report a problem with these data
Target
Phospholipase D2
Ligand
BDBM50206156
Substrate
n/a
Meas. Tech.
ChEMBL_454676 (CHEMBL886696)
IC50
20±n/a nM
Citation
 Monovich, L; Mugrage, B; Quadros, E; Toscano, K; Tommasi, R; LaVoie, S; Liu, E; Du, Z; LaSala, D; Boyar, W; Steed, P Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett 17:2310-1 (2007) [PubMed]  Article 
Target
Name:
Phospholipase D2
Synonyms:
PLD2 | PLD2_HUMAN | Phospholipase D2 | Phospholipase D2 (PLD2) | phospholipase D2 isoform PLD2A
Type:
Protein
Mol. Mass.:
106002.47
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
933
Sequence:
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
  
Inhibitor
Name:
BDBM50206156
Synonyms:
CHEMBL246240 | N-(2-(4-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H25N5O2
Mol. Mass.:
403.4769
SMILES:
O=C(NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O)c1cc2ccccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: