Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50212700
Substrate
n/a
Meas. Tech.
ChEMBL_447328 (CHEMBL896362)
IC50
148±n/a nM
Citation
 Bratton, LD; Filzen, GF; Geyer, A; Hoffman, JK; Lu, G; Pulaski, J; Trivedi, BK; Unangst, PC; Xu, X Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists. Bioorg Med Chem Lett 17:3624-9 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50212700
Synonyms:
2-(7-(4-(4-tert-butylbenzyloxy)benzylthio)-2,3-dihydro-1H-inden-4-yloxy)acetic acid | CHEMBL392949
Type:
Small organic molecule
Emp. Form.:
C29H32O4S
Mol. Mass.:
476.627
SMILES:
CC(C)(C)c1ccc(COc2ccc(CSc3ccc(OCC(O)=O)c4CCCc34)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: