Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha
Ligand
BDBM50214446
Substrate
n/a
Meas. Tech.
ChEMBL_439083 (CHEMBL889431)
Ki
24±n/a nM
Citation
 Nie, Z; Perretta, C; Erickson, P; Margosiak, S; Almassy, R; Lu, J; Averill, A; Yager, KM; Chu, S Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2. Bioorg Med Chem Lett 17:4191-5 (2007) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
ACK2 | CK II | CK2- alpha | CSK2A_MAIZE | Casein Kinase II
Type:
Enzyme
Mol. Mass.:
39238.74
Organism:
Zea mays (Maize)
Description:
n/a
Residue:
332
Sequence:
MSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNVYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTRA
  
Inhibitor
Name:
BDBM50214446
Synonyms:
2,4-bis(phenylamino)pyrazolo[1,5-a][1,3,5]triazine-8-carbonitrile | CHEMBL396230
Type:
Small organic molecule
Emp. Form.:
C18H13N7
Mol. Mass.:
327.3427
SMILES:
N#Cc1cnn2c(Nc3ccccc3)nc(Nc3ccccc3)nc12
Structure:
Search PDB for entries with ligand similarity: