Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50216434
Substrate
n/a
Meas. Tech.
ChEMBL_456638 (CHEMBL922993)
IC50
10±n/a nM
Citation
 Lagu, B; Gerchak, C; Pan, M; Hou, C; Singer, M; Malaviya, R; Matheis, M; Olini, G; Cavender, D; Wachter, M Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma. Bioorg Med Chem Lett 17:4382-6 (2007) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50216434
Synonyms:
CHEMBL245686 | dimethyl-(tetrahydro-pyran-4-yl)-{4-[(E)-3-(4'-trifluoromethyl-biphenyl-4-yl)-acryloylamino]-benzyl}-ammonium
Type:
Small organic molecule
Emp. Form.:
C30H32F3N2O2
Mol. Mass.:
509.5819
SMILES:
C[N+](C)(Cc1ccc(NC(=O)\C=C\c2ccc(cc2)-c2ccc(cc2)C(F)(F)F)cc1)C1CCOCC1
Structure:
Search PDB for entries with ligand similarity: