Reaction Details Report a problem with these data
Target
Sodium- and chloride-dependent glycine transporter 2
Ligand
BDBM50218012
Substrate
n/a
Meas. Tech.
ChEMBL_456973 (CHEMBL923316)
IC50
>30000±n/a nM
Citation
 Walter, MW; Hoffman, BJ; Gordon, K; Johnson, K; Love, P; Jones, M; Man, T; Phebus, L; Reel, JK; Rudyk, HC; Shannon, H; Svensson, K; Yu, H; Valli, MJ; Porter, WJ Discovery and SAR studies of novel GlyT1 inhibitors. Bioorg Med Chem Lett 17:5233-8 (2007) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 2
Synonyms:
GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
87438.56
Organism:
Homo sapiens (Human)
Description:
Glycine-2-transporter 0 HUMAN::Q9Y345
Residue:
797
Sequence:
MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQTFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHCKIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
  
Inhibitor
Name:
BDBM50218012
Synonyms:
({2-[4-(2,3-dihydro-benzofuran-5-yl)-2-thiophen-2-yl-phenoxy]-ethyl}-methyl-amino)-acetic acid | CHEMBL399034
Type:
Small organic molecule
Emp. Form.:
C23H23NO4S
Mol. Mass.:
409.498
SMILES:
CN(CCOc1ccc(cc1-c1cccs1)-c1ccc2OCCc2c1)CC(O)=O
Structure:
Search PDB for entries with ligand similarity: