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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50262554
Substrate
n/a
Meas. Tech.
ChEMBL_509554 (CHEMBL997868)
Ki
>1000±n/a nM
Citation
 Sato, N; Jitsuoka, M; Shibata, T; Hirohashi, T; Nonoshita, K; Moriya, M; Haga, Y; Sakuraba, A; Ando, M; Ohe, T; Iwaasa, H; Gomori, A; Ishihara, A; Kanatani, A; Fukami, T (9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist. J Med Chem 51:4765-70 (2008) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50262554
Synonyms:
9-(2-Hydroxy-4,4-dimethyl-6-oxocyclohexyl)-8-methoxy-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one | CHEMBL477367
Type:
Small organic molecule
Emp. Form.:
C24H28O5
Mol. Mass.:
396.4761
SMILES:
COc1cccc2OC3=C(C(C4C(=O)CC(C)(C)CC4=O)c12)C(=O)CC(C)(C)C3 |c:8|
Structure:
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