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Target
Histone deacetylase 1
Ligand
BDBM50268121
Substrate
n/a
Meas. Tech.
ChEMBL_521103 (CHEMBL960364)
IC50
3.2±n/a nM
Citation
 Andrianov, V; Gailite, V; Lola, D; Loza, E; Semenikhina, V; Kalvinsh, I; Finn, P; Petersen, KD; Ritchie, JW; Khan, N; Tumber, A; Collins, LS; Vadlamudi, SM; Björkling, F; Sehested, M Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR. Eur J Med Chem 44:1067-85 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50268121
Synonyms:
(E)-3-(4-Chloro-2-fluorophenyl)-N-[6-(hydroxyamino)-6-oxohexyl]-2-propenamide | CHEMBL484489
Type:
Small organic molecule
Emp. Form.:
C15H18ClFN2O3
Mol. Mass.:
328.766
SMILES:
ONC(=O)CCCCCNC(=O)\C=C\c1ccc(Cl)cc1F
Structure:
Search PDB for entries with ligand similarity: