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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50273799
Substrate
n/a
Meas. Tech.
ChEMBL_538311 (CHEMBL1036745)
IC50
883.1±n/a nM
Citation
 Simoni, D; Gebbia, N; Invidiata, FP; Eleopra, M; Marchetti, P; Rondanin, R; Baruchello, R; Provera, S; Marchioro, C; Tolomeo, M; Marinelli, L; Limongelli, V; Novellino, E; Kwaasi, A; Dunford, J; Buccheri, S; Caccamo, N; Dieli, F Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism. J Med Chem 51:6800-7 (2008) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324
Type:
Enzyme
Mol. Mass.:
48272.89
Organism:
Homo sapiens (Human)
Description:
P14324
Residue:
419
Sequence:
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
  
Inhibitor
Name:
BDBM50273799
Synonyms:
CHEMBL452354 | [2-(6-Chloro-purin-9-yl)ethyl]-bisphosphonic acid
Type:
Small organic molecule
Emp. Form.:
C7H9ClN4O6P2
Mol. Mass.:
342.57
SMILES:
OP(O)(=O)C(Cn1cnc2c(Cl)ncnc12)P(O)(O)=O
Structure:
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