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Target
Histone deacetylase 1
Ligand
BDBM50277257
Substrate
n/a
Meas. Tech.
ChEMBL_540427 (CHEMBL1029044)
IC50
>10000±n/a nM
Citation
 Wahhab, A; Smil, D; Ajamian, A; Allan, M; Chantigny, Y; Therrien, E; Nguyen, N; Manku, S; Leit, S; Rahil, J; Petschner, AJ; Lu, AH; Nicolescu, A; Lefebvre, S; Montcalm, S; Fournel, M; Yan, TP; Li, Z; Besterman, JM; Déziel, R Sulfamides as novel histone deacetylase inhibitors. Bioorg Med Chem Lett 19:336-40 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50277257
Synonyms:
6-(N-acetylsulfamoylamino)-N-(biphenyl-3-yl)hexanamide | CHEMBL515256
Type:
Small organic molecule
Emp. Form.:
C20H25N3O4S
Mol. Mass.:
403.495
SMILES:
CC(=O)NS(=O)(=O)NCCCCCC(=O)Nc1cccc(c1)-c1ccccc1
Structure:
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