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Target
Adenosine receptor A2a
Ligand
BDBM50266442
Substrate
n/a
Meas. Tech.
ChEMBL_516361 (CHEMBL987748)
Ki
275±n/a nM
Citation
 Lanier, MC; Moorjani, M; Luo, Z; Chen, Y; Lin, E; Tellew, JE; Zhang, X; Williams, JP; Gross, RS; Lechner, SM; Markison, S; Joswig, T; Kargo, W; Piercey, J; Santos, M; Malany, S; Zhao, M; Petroski, R; Crespo, MI; Díaz, JL; Saunders, J; Wen, J; O'Brien, Z; Jalali, K; Madan, A; Slee, DH N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy. J Med Chem 52:709-17 (2009) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50266442
Synonyms:
CHEMBL515218 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-[(R)-2-(2-methoxyethyl)piperidin-1-yl]pyrimidin-4-yl]acetamide
Type:
Small organic molecule
Emp. Form.:
C19H28N6O2
Mol. Mass.:
372.4646
SMILES:
COCC[C@@H]1CCCCN1c1cc(NC(C)=O)nc(n1)-n1nc(C)cc1C |r|
Structure:
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