Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50277251
Substrate
n/a
Meas. Tech.
ChEMBL_540738 (CHEMBL1030620)
EC50
65±n/a nM
Citation
 Dounay, AB; Barta, NS; Bikker, JA; Borosky, SA; Campbell, BM; Crawford, T; Denny, L; Evans, LM; Gray, DL; Lee, P; Lenoir, EA; Xu, W Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists. Bioorg Med Chem Lett 19:1159-63 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50277251
Synonyms:
4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(3-methoxypropyl)pyrimidin-2-amine | CHEMBL474090
Type:
Small organic molecule
Emp. Form.:
C23H31N5O
Mol. Mass.:
393.5251
SMILES:
COCCCNc1nccc(n1)C1CCCN(CCc2c[nH]c3ccccc23)C1
Structure:
Search PDB for entries with ligand similarity: