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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50248114
Substrate
n/a
Meas. Tech.
ChEMBL_566228 (CHEMBL963309)
Ki
79±n/a nM
Citation
 Biju, P; Taveras, AG; Yu, Y; Zheng, J; Hipkin, RW; Fossetta, J; Fan, X; Fine, J; Lundell, D 3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists. Bioorg Med Chem Lett 19:1434-7 (2009) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:
Protein
Mol. Mass.:
40767.88
Organism:
Homo sapiens (Human)
Description:
P25025
Residue:
360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
  
Inhibitor
Name:
BDBM50248114
Synonyms:
(R)-N-(2-cyanoethyl)-2-hydroxy-3-(4-(1-(4-isopropylfuran-2-yl)-2,2-dimethylpropylamino)-1,2,5-thiadiazol-3-ylamino)-N-methylbenzamide | CHEMBL462156
Type:
Small organic molecule
Emp. Form.:
C25H32N6O3S
Mol. Mass.:
496.625
SMILES:
CC(C)c1coc(c1)[C@H](Nc1nsnc1Nc1cccc(C(=O)N(C)CCC#N)c1O)C(C)(C)C |r|
Structure:
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