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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50258049
Substrate
n/a
Meas. Tech.
ChEMBL_566697 (CHEMBL961689)
Ki
1200±n/a nM
Citation
 Holl, R; Schepmann, D; Fröhlich, R; Grünert, R; Bednarski, PJ; Wünsch, B Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity. J Med Chem 52:2126-37 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50258049
Synonyms:
(-)-(1S,5S,Z)-6-Allyl-2-benzylidene-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane | CHEMBL492566
Type:
Small organic molecule
Emp. Form.:
C25H30N2O
Mol. Mass.:
374.5185
SMILES:
COc1ccc(CN2C[C@@H]3CC\C(=C\c4ccccc4)[C@H]2CN3CC=C)cc1 |r,TLB:13:12:22.21:8.7,6:7:22.21:12.10.11,THB:23:22:12.10.11:8.7|
Structure:
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