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Target
Thromboxane A2 receptor
Ligand
BDBM50283043
Substrate
n/a
Meas. Tech.
ChEBML_210264
IC50
57±n/a nM
Citation
 Vlattas, I; Dellureficio, J; Cohen, DS; Lee, W; Clarke, F; Dotson, R; Mathis, J; Zoganas, H Thia-prostanoid analogs with combined thromboxane receptor antagonist/thromboxane synthase inhibitor activities. Synthesis and pharmacological evaluation Bioorg Med Chem Lett 4:2067-2072 (1994)    Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50283043
Synonyms:
(Z)-7-[(2S,3S,4R)-4-(Biphenyl-4-ylmethoxy)-1-oxo-2-pyridin-3-yl-tetrahydro-1lambda*4*-thiophen-3-yl]-hept-4-enoic acid | CHEMBL62852
Type:
Small organic molecule
Emp. Form.:
C29H31NO4S
Mol. Mass.:
489.626
SMILES:
OC(=O)CC\C=C/CC[C@H]1[C@H](CS(=O)[C@@H]1c1cccnc1)OCc1ccc(cc1)-c1ccccc1
Structure:
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