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Target
Type-2 angiotensin II receptor
Ligand
BDBM50283163
Substrate
n/a
Meas. Tech.
ChEBML_35563
IC50
500±n/a nM
Citation
 Olson, RE; Liu, J; Lalka, GK; VanAtten, MK; Wexler, RR; Chiu, AT; Nguyen, TT; McCall, DE; Wong, PC; Timmermans, PB Balanced angiotensin II receptor antagonists. II.1,2 4-aminomethyl- and acylaminomethylimidazoles Bioorg Med Chem Lett 4:2229-2234 (1994)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50283163
Synonyms:
2-Ethyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid | CHEMBL70389
Type:
Small organic molecule
Emp. Form.:
C30H31N9O2
Mol. Mass.:
549.6262
SMILES:
CCc1nc(CN2CCN(CC2)c2ccccn2)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Structure:
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